Genotoxic stresses and protein modifications
نویسندگان
چکیده
منابع مشابه
Genotoxic stresses and protein modifications.
Genotoxic stresses such as DNA damage or abnormal chromosome segregation induced by various extrinsic or intrinsic factors often take place in all kinds of cells, which play important roles in tumorigenesis. Organisms have developed many molecular mechanisms regarding these genotoxic stresses during the evolutional progress. Protein postmodifications such as phosphorylation or sumoylation have ...
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The p53 tumor suppressor is a tetrameric transcription factor that is posttranslational modified at -1 8 different sites by phosphorylation, acetylation, or sumoylation in response to various cellular stress conditions. Specific posttranslational modifications, or groups of modifications, that result from the activation of different stress-induced signaling pathways are thought to modulate p53 ...
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Cell division cycle 2 (Cdc2) protein is an essential subunit of M-phase kinase (MPK), which has a key role in G2/M transition. Even though the control of MPK activity has been well established with regard to the phosphorylation of Cdc2 at Thr 14 and/or Tyr 15 and Thr 161, little is known about the proteolytic control of Cdc2. In this study, we observed that Cdc2 was downregulated under genotoxi...
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Depletion of the major heat shock protein Hsp72 leads to activation of the senescence program in a variety of tumor cell lines via both p53-dependent and p53-independent pathways. Here, we found that the Hsp72-depleted cells show defect in phosphorylation and activation of the protein kinase Chk1 by genotoxic stresses, such as UVC irradiation or camptothecin. Under these conditions, phosphoryla...
متن کاملIdentification and Expression Analysis of Two Arabidopsis LRR-Protein Encoding Genes Responsive to Some Abiotic Stresses
AbstractTwo Arabidopsis thaliana genes, psr9.2 and psr9.4 appearedto be highly similar to a phosphate-starved induced gene,psr9, isolated from Brassica nigra suspension cells.Sequence analysis classified the encoded polypeptides asmembers of leucine-rich repeat (LRR) proteins superfamily.The sequence of psr9 proteins comprise a unique N-terminalregion e...
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ژورنال
عنوان ژورنال: Journal of Molecular Cell Biology
سال: 2012
ISSN: 1674-2788
DOI: 10.1093/jmcb/mjs051